Existence of independent C/EBPβ3'-UTR RNA in human tissues
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摘要:
Two years ago,it was found that the RNA expressed from the promoter in the 3'-untranslated region (UTR) of a gene,i.e.independent 3'-UTR RNA,exists widely in human,mouse,and fly [1].
We have found that an RNA from the 3'-UTR of C/EBPβgene is a tumor suppressor [2-7].Because in our experiments this RNA is artificially introduced into malignant cells,until recently it was not clear if the RNA from C/EBPβ 3'-UTR,i.e.independently expressed C/EBPβ3'-UTR RNA,naturally exists in human cells.