Speckle-type POZ protein mutations interrupt tumor suppressor function of speckle-type POZ protein in prostate cancer by affecting androgen receptor degradation

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2014,（5）
• 页码范围: 659-660
• 页数: 2页
• 语种: 中文
• DOI: 10.4103/1008-682X.133323

摘要

Large scale exome sequencing studies have revealed regions of the genome,which contribute to the castrate resistant prostate cancer (CRPC) phenotype.1-3 Such studies have identified mutations in genes,which may have diagnostic/prognostic potential,or which may be targeted therapeutically.Two of these genes include the androgen receptor (AR) and speckle-type POZ protein (SPOP) genes.However,the findings from these exome sequencing studies can only be translated therapeutically once the functional consequences of these mutations have been determined.Here,we highlight the recent study by An et al.4 which investigated the functional effects of mutations in the SPOP gene that were identified in the aforementioned exome sequencing studies,particularly in the context of SPOP-mediated degradation of the AR.