Generation of transgenic golden Syrian hamsters

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2014,（3）
• 页码范围: 380-382
• 页数: 3页
• 语种: 英文
• DOI: 10.1038/cr.2014.2

摘要

Dear Editor, Golden Syrian hamsters are small rodents,but they display many features that resemble the physiology and metabolism of humans.Hamsters have been widely used in many research areas,including carcinogenesis [1],reproduction [2],virology [3],diabetes [4] and cardiovascular diseases [5].With respect to lipid and glucose metabolism,hamsters,like humans,exhibit high levels of cholesteryl ester transport protein (CETP),intestinalonly ApoB editing,low levels of hepatic low-density lipoprotein (LDL) receptor activity [6] and a high glycemic response to dietary fructose [7],all of which are not observed in other rodents such as mice and rats.Consequently,hamsters,like humans,exhibit enhanced susceptibility to atherosclerosis (AS) and diabetes [8],which led to the widespread use of hamsters in studies on AS and diabetes.