Driving glioblastoma growth by alternative polyadenylation

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2014,（9）
• 页码范围: 1023-1024
• 页数: 2页
• 语种: 中文
• DOI: 10.1038/cr.2014.88

摘要

Global shortening of 3' untranslated regions (3'UTRs) through alternative polyadenylation is an emerging hallmark of cancer.A recent study identifies the cleavage factor Im 25 (CFIm25) as an important mediator of 3' UTR shortening in glioblastomas and demonstrates a causal relationship between alternative polyadenylation and cancer cell proliferation.