Blood loses it when nerves go bad

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2014,（10）
• 页码范围: 1151-1152
• 页数: 2页
• 语种: 中文
• DOI: 10.1038/cr.2014.98

摘要

Myeloproliferative neoplasms are diseases that arise in the stem cells of the blood.In a recent paper published in Nature,Arranz et al.demonstrated that abrogation of sympathetic nerve fibers reduced bone marrow Nestin+mesenchymal cells,which in turn led to an expansion of hematopoietic stem cells and progression of myeloproliferative neoplasms. The stromal cell compartment,or non-hematopoietic cells,of the bone marrow has emerged as an important driver of cell state in hematopoietic stem cells (HSCs) and hematopoietic stem/progenitor cells (HSPCs) in a nonautonomous manner.