LeA(H)Rning self-control

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2014,（10）
• 页码范围: 1155-1156
• 页数: 2页
• 语种: 中文
• DOI: 10.1038/cr.2014.96

摘要

The aryl hydrocarbon receptor (AhR) is an important regulator of the immune response.A report by Puccetti and coworkers describes a regulatory pathway by which L-kynurenine (L-Kyn) produced by tryptophan 2,3-dioxygenase 2 (TDO2) activates AhR in cells of the innate immune system to limit endotoxin-triggered inflammation through a mechanism that involves the non-enzymatic anti-inflammatory activities of indoleamine 2,3-dioxygenase 1 (IDO1).