This Special Topic:Mass Spectrometry Analysis,covers recent experimental results and advances in the analytical field of Mass Spectrometry (MS) for organic and metabolic molecules,and bio-molecules.Recently,the instrumentation of mass spectrometers has been improved greatly in terms of its sensitivity,resolution,accuracy and precision.For example,the high resolution for daily running-horse instruments can now reach to 20×103-40×103 for time-offlight (TOF) based MSs,and 50×103-50×104 for ObTrap based ones.The data acquisition rate also becomes faster and faster,so that the speed advantage promotes metabolome and proteome to be real omic tools now.The improvements of MS instruments have provided scientist more space to explore the exciting research areas including organic chemistry,environmental chemistry,and biochemistry and life science.