Regeneration: making muscle from hPSCs

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2014,（10）
• 页码范围: 1159-1161
• 页数: 3页
• 语种: 中文
• DOI: 10.1038/cr.2014.91

摘要

In recent years,researchers worldwide have developed protocols to efficiently differentiate skeletal myogenic cells from human pluripotent stem cells through either ectopic gene expression or the use of small molecules.These stem cell-derived myogenic cells provide new avenues for the study of muscle-related diseases,drug screening and are potentially a new tool for cell therapy against muscular dystrophies. Muscular dystrophies (MDs) are heterogeneous genetic diseases that progressively affect the growth and regeneration of skeletal muscle.In the past decade,significant advancements to promote the efficient regeneration of various human tissues,including skeletal muscle,have been achieved.