Expanding the functional role of long noncoding RNAs

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2014,（11）
• 页码范围: 1284-1285
• 页数: 2页
• 语种: 中文
• DOI: 10.1038/cr.2014.104

摘要

New findings bring to light a previously unappreciated mechanism involved in the regulation of the oncoprotein MYC.Interesting observations find that the long noncoding RNA (lncRNA) PVT1 is active in controlling levels of MYC through regulation of MYC protein stability. The oncogene MYC is localized in the chromosomal region 8q24.21,a region frequently amplified in many human tumors.In addition to MYC,this locus also hosts the GSDMC and CCDC26 genes as well as the lncRNA PVT1.A gain of function for all of these genes is observed in many tumors along with MYC.