Crystal structure and biochemical analysis of the heptameric Lsm1-7 complex

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2014,（4）
• 页码范围: 497-500
• 页数: 4页
• 语种: 英文
• DOI: 10.1038/cr.2014.18

摘要

Dear Editor, The Lsm (Sm-like) family of proteins,characterized by the Sm fold [1] and conserved among eukaryotes,plays an important role in RNA biogenesis.The Sm and Lsm complexes play an essential role in pre-mRNA splicing [2].Of the five small ribonucleoproteins (snRNPs),four (U1,U2,U4,U5) contain the Sm heptamer ring,whereas the U6 snRNP contains a specific Lsm2-8 heptamer that comprises Lsm2,Lsm3,Lsm4,Lsm5,Lsm6,Lsm7,and Lsm8 [3].Another Lsm heptameric complex,Lsm1-7,which differs from Lsm2-8 by one Lsm protein,is thought to function in mRNA decapping,a crucial step in the mRNA degradation pathway [4].