3-49 X-ray Radiation Induced Caspase-8 and Caspase-9 Activation in Human Colon Cancer Cells

• 作者: Li Ping Li Qiang Liu Bingtao Liu Xiongxiong
• 来源期刊: 中国科学院近代物理研究所和兰州重离子研究装置年报：英文版
• 学科: 物理学
• 关键词: RADIATION INDUCED ACTIVATION
• 年，卷（期）: 2014,（1）
• 页码范围: 143-143
• 页数: 1页
• 分类号: O4

摘要

Caspases as critical components in cell signaling pathways have been proved to be involved in events such asapoptosis, cell growth and differentiation. Two distinct apoptotic pathways related to the Caspase cascade have beenidentified; death receptor-induced apoptosis and mitochondrial stress-induced apoptosis. Death receptors triggerCaspase-8 and the mitochondria subsequently release apoptogenic factors (cytochrome c, Apaf-1, AIF), leading tothe activation of Caspase-9. The mitochondrial and death receptor apoptotic pathways are intimately connected[1].