The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2014,（9）
• 页码范围: 1137-1140
• 页数: 4页
• 语种: 中文
• DOI: 10.1038/cr.2014.55

摘要

Dear Editor, In eukaryotes,increased protein folding demand at the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) [1],which plays a pivotal role in control of cellular functions and survival under ER stress [2].Chronic ER stress is thought to contribute to the pathogenic progression of diabetes [3,4].Inositol-requiring enzyme 1 (IRE 1),an ER-resident transmembrane Ser/Thr protein kinase and endoribonuclease,is the most conserved ER stress sensor that mediates a key branch of the UPR [1].