Structure and domain organization of Drosophila Tudor
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摘要:
Dear Editor,
Drosophila tudor is a maternal effect gene required for germ cell formation and abdominal segmentation during oogenesis [1,2].It encodes a large protein,Tudor (Tud),of 2 515 amino acids,containing 11 copies of a ~60-residue sequence motif,termed the tudor domain.Tudor domains are best characterized by their methyllysine and methylarginine binding abilities [3-5].Biochemically,Tud interacts with Aubergine (Aub),a Piwi family protein,in a manner dependent on symmetrically dimethylated arginine (sDMA) residues located at the N-terminal end of Aub [6-8].The sDMA-dependent interaction between Tud and Aub is part of a broad range of phenomena involving tudor domain and Piwi family proteins,in species ranging from fruit flies to mammals [3].