Osteogenic fate of hypertrophic chondrocytes

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2014,（10）
• 页码范围: 1266-1269
• 页数: 4页
• 语种: 中文
• DOI: 10.1038/cr.2014.111

摘要

Dear Editor, Endochondral bone formation is largely dependent on cartilage lineage cells.The chondrocytes in growth plates continuously undergo a sequential process from proliferation to terminal hypertrophic differentiation [1].Once differentiated,hypertrophic chondrocytes elicit multiple functions such as determining bone length,inducing osteogenesis as well as directing bone mineralization,and eventually disappear at the chondro-osseous junction.