Ultrastructural changes and asthenozoospermia in murine spermatozoa lacking the ribosomal protein L29/HIP gene
基本信息来源于合作网站,原文需代理用户跳转至来源网站获取
摘要:
Dear Editor,
We present here the first report linking a specific gene,ribosomal protein L29 (Rp129),also known as Hip (heparin/heparan sulfate interacting protein),to the mammalian sperm flagellar morphological anomaly termed the "dag" defect.In addition,we show that loss of Rpl29 invariably results in low sperm motility with infertility accompanying this abnormality.
Ribosomal protein L29 is one of 79 Rps that regulate the efficiency of protein synthesis.Expressed in a variety of tissues,including the testis,it is a constituent ofmembrane-associated and cytoplasmic translationally-active ribosomes.1 It has been suggested that along with RPl10,it participates in the process of coupling of the 40S and 60S subunits during translation initiation.2 Abnormalities in expression of Rts are known to manifest in various ribosomopathies.3 However,neither human RP spontaneous mutations nor specific gene-targeting strategies reported in mice,have been previously associated with sperm or fertility abnormalities.