Gold-catalyzed chemo-and site-selective direct C-H functionalization of phenols with diazo compounds

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2014,（8）
• 页码范围: 1057
• 页数: 1页
• 语种: 中文
• DOI: 10.1007/s11426-014-5167-y

摘要

Phenols motifs are used as common versatile synthons in organic synthesis due to their wide availability and low cost.Thus,C-H functionalization of phenols is highly attractive to the community of synthetic chemistry.In the past decade,many methods have been developed via installing a protective group on the hydroxyl to allow for ortho/meta/para functionalization of phenols.One of the most effective methods for direct C-H functionalization is the carbene transfer reaction of diazo compounds catalyzed by transition-metal complexes,such as rhodium,copper,silver,palladium,etc.However,direct C-H functionalization of phenols with diazo compounds remains to be highly challenging because the reactive O-H bond could lead to competitive chemoselective O-H bond insertion in the presence of various transition-metal catalysts.