Risk factors for hypospadias in China

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2014,（9）
• 所属期刊栏目: ORIGINAL ARTICLE
• 页码范围: 778-781
• 页数: 4页
• 语种: 英文
• DOI: 10.4103/1008-682X.131704

摘要

This case?controlled study was designed to evaluate the association between various baseline parental factors and the risk of hypospadias in China. Patients were selected from tertiary referral hospitals in Anhui, a province in mid?eastern China. Aquestionnaire was given to the parents of each patient. The ifnal database included 193cases and 835 controls. The incidence of additional coexistent anomalies was 13.0%, primarily cryptorchidism(9.8%). Ten patients(5.1%) were from families with genital anomaly, including ifve families(2.6%) with hypospadias. The risks of hypospadias was higher for children of mothers>35 (odds ratio[OR] =1.47) and<18(OR=2.95) years of age, and in mothers who had consumed alcohol(OR=2.67), used drugs(OR=1.53) and had an infection(OR=1.87) during pregnancy. The risk of hypospadias was also higher when mothers(OR=1.68) and fathers(OR=1.74) were engaged in agriculture. Other factors assessed were not associated with the risk of hypospadias.