Chronic alcohol consumption potentiates the development of diabetes through pancreatic β-cell dysfunction

• 作者: Dae Yeon Lee Jae Woo Kim Ji Yeon Kim Keon Jae Park Kyu Hee Kim Won-Ho Kim Yoo Jeong Lee
• 来源期刊: 世界生物化学杂志：英文版（电子版）
• 学科: 医学
• 关键词: Ethanol consumption Type 2 DIABETES PANCREATIC β-cells GLUCOKINASE Metabolic syndrome
• 年，卷（期）: 2015,（1）
• 页码范围: 1-15
• 页数: 15页
• 分类号: R587.1

摘要

Chronic ethanol consumption is well established as a major risk factor for type-2 diabetes(T2D), which is evidenced by impaired glucose metabolism and insulin resistance. However, the relationships between alcoholconsumption and the development of T2 D remain controversial. In particular, the direct effects of ethanol consumption on proliferation of pancreatic β-cell and the exact mechanisms associated with ethanolmediated β-cell dysfunction and apoptosis remain elusive. Although alcoholism and alcohol consumption are prevalent and represent crucial public health problems worldwide, many people believe that low-tomoderate ethanol consumption may protect against T2 D and cardiovascular diseases. However, the J- or U-shaped curves obtained from cross-sectional and large prospective studies have not fully explained the relationship between alcohol consumption and T2 D. This review provides evidence for the harmful effects of chronic ethanol consumption on the progressive development of T2 D, particularly with respect to pancreatic β-cell mass and function in association with insulin synthesis and secretion. This review also discusses a conceptual framework for how ethanolproduced peroxynitrite contributes to pancreatic β-cell dysfunction and metabolic syndrome.