基本信息来源于合作网站,原文需代理用户跳转至来源网站获取       
摘要:
We conducted a single-center, prospective clinical trial in which a subcutaneous bortezomib (Bor) regimen [1.6 mg/m2 per month (BD 1.6 mg/m2 therapy)] was administered to 22 multiple myeloma patients. All patients had been treated sufficiently with once-monthly subcutaneous Bor injections (BD 1.3 mg/m2therapy). Of the 22 patients, 13 had IgG-, 2 had IgA-, and 7 had Bence-Jones protein (BJP)-type multiple myeloma. The observation period for therapeutic effect determination ranged from 84 to 412 days (median: 400 days). Therapeutic effects were investigated in 15 patients during the increase in Bor from 1.3 to 1.6 mg/m2, and none achieved complete remission (CR), very good partial remission (VGPR), or partial remission (PR). Given the small number of patients, a significant conclusion must be reached carefully. However, the chance of stronger success with increases in Bor is low for patients who have already undergone long-term 1.3 mg/m2 Bor treatment. Furthermore, non-hematological toxicity was seen in 12 of 22 patients, so increasing Bor to 1.6 mg/m2 should be considered carefully. However, the statuses of patients in this study suggest that once-monthly Bor could inhibit disease progression. In future we should investigate low-frequency Bor maintenance therapy.
推荐文章
弹簧钢SUP9D超声探伤缺陷分析
SUP9D弹簧钢
超声探伤
夹杂物
中间包
肾结石患者尿β2-MG、NAG和γ-GT的变化及临床意义
肾脏结石
β2-微球蛋白
N-乙酰-β-D-葡萄糖苷酶
γ-谷氨酰胺转移酶
SUP-13配合比设计中若干问题的探讨
SUP-13
配合比
设计方法
浅析sup改性沥青混凝土配合比设计要点
SBS改性沥青
混凝土
配合比设计
浅析
内容分析
关键词云
关键词热度
相关文献总数  
(/次)
(/年)
文献信息
篇名 The Efficacy and Safety of a 1.6 mg/m<sup>2</sup>Increase in a Bortezomib Regimen
来源期刊 血液病期刊(英文) 学科 医学
关键词 Multiple MYELOMA BORTEZOMIB Maintenance THERAPY
年,卷(期) 2015,(1) 所属期刊栏目
研究方向 页码范围 1-8
页数 8页 分类号 R73
字数 语种
DOI
五维指标
传播情况
(/次)
(/年)
引文网络
引文网络
二级参考文献  (0)
共引文献  (0)
参考文献  (0)
节点文献
引证文献  (0)
同被引文献  (0)
二级引证文献  (0)
2015(0)
  • 参考文献(0)
  • 二级参考文献(0)
  • 引证文献(0)
  • 二级引证文献(0)
研究主题发展历程
节点文献
Multiple
MYELOMA
BORTEZOMIB
Maintenance
THERAPY
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
血液病期刊(英文)
季刊
2164-3180
武汉市江夏区汤逊湖北路38号光谷总部空间
出版文献量(篇)
110
总下载数(次)
0
论文1v1指导