Biodegradable mineralized collagen plug for the reconstruction of craniotomy burr‐holes:A report of three cases

• 作者: Fuzhai Cui Tianxi Song Yuqi Zhang Zhiye Qiu Ziqiang Zhang
• 来源期刊: 临床转化神经医学(英文版)
• 学科: 医学
• 年，卷（期）: sjkxyw_2015,（1）
• 页码范围: 3-9
• 页数: 7页
• 分类号: R318.08

摘要

Objectives: In this case report, we describe the design, fabrication and clinical outcomes of a novel bioresorbable, mineralized collagen burr‐hole plug for the reconstruction of craniotomy burr‐holes. Methods: Mineralized collagen burr‐hole plugs were fabricated via a biomimetic mineralization process. The biomimetic mineralized collagen has a similar chemical composition and microstructure to natural bone tissue, thereby possessing good biocompatibility and osteoconductivity. The mineralized collagen burr‐hole plugs were implanted into three patients, and clinical outcomes were evaluated at one‐year follow‐ups. Results: All bone defects healed very well using the mineralized collagen burr‐hole plugs, and there were no adverse reactions at the surgical sites. Conclusions: The clinical outcomes indicated that the mineralized collagen was effective for reconstructing burr‐holes in the skull after craniotomy.