New therapies for chronic obstructive pulmonary disease,lung regeneration

• 作者: Masaki Fujita
• 来源期刊: 世界呼吸病学杂志
• 学科: 医学
• 关键词: EMPHYSEMA Chronic INFLAMMATION Stem cell RETINOIC acid TypeⅡcells
• 年，卷（期）: sjhxbxzz_2015,（1）
• 页码范围: 34-39
• 页数: 6页
• 分类号: R

摘要

Chronic obstructive pulmonary disease(COPD)is characterized by the presence of airflow limitations that are not fully reversible and is a major cause of chronic morbidity and mortality worldwide.Although there has been extensive research examining the molecular mechanisms underlying the development of COPD,there is no proven clinically effective treatment for promoting recovery from established COPD.At present,regeneration is the only hope for a cure in patients with COPD.In this article,we review current treatments for COPD,focusing particularly on recent advances in lung regeneration based on two major approaches:regeneration-promoting agents and cell therapy.Retinoic acids are the major focus among regeneration-promoting agents,while mesenchymal stem cells are the main topic in the field of cell-based therapy.This article aims to provide valuable information for developing new therapies for COPD.