Synthesis, Reactions and Antimicrobial Activity of Some New 3-Substituted Indole Derivatives

• 作者: Anhar Abdel-Aziem Asmaa S. Salman Doaa M. Elsisi Mona A. Mohamed Naema A. Mahmoud
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: Indole-3-Carboxaldehyde Acid HYDRAZIDE 1 3-Thiazole PYRIMIDINE ANTIMICROBIAL
• 年，卷（期）: 2015,（2）
• 页码范围: 81-99
• 页数: 19页
• 分类号: O6

摘要

Reaction of indole-3-carboxaldehydes 4 with hydrazine derivatives and different substituted acid hydrazides afforded the corresponding hydrazine derivatives 5a-c and acid hydrazide derivatives 7-11 respectively. Condensation of indole-3-carboxaldehydes 4 with phenacyl bromide and thiourea gives 1,3-thiazol-2-amine derivative 18. On the other hand, reaction 4 with 3-acetylchromene-2-one afforded chalcone derivative 19. Compound 4 undergoing Knoevenagel condensation with cyanoacetamide, ethyl cyanoacetate, benzimidazol-2-ylacetonitrile, rhodanine-3-acetic acid, 2,3-dihydropyrimidin-4-one derivative and 2,4-dihydropyrazol-3-one afforded the compounds 20a,b, 22, 23, 27 and 28 respectively. The structure of the newly synthesized compounds has been confirmed by elemental analysis and spectra data. The antimicrobial activities of the some newly synthesized compounds were measured and showed that most of them have high activities