Is erythroferrone finally the long sought-after systemic erythroid regulator of iron?

• 作者: Alfons Lawen
• 来源期刊: 世界生物化学杂志：英文版（电子版）
• 学科: 生物学
• 关键词: ERYTHROID REGULATOR of IRON HEPCIDIN IRON METABOLISM Myonectin SYSTEMIC IRON regulation
• 年，卷（期）: 2015,（3）
• 页码范围: 78-82
• 页数: 5页
• 分类号: Q25

摘要

Iron metabolism is regulated on the cellular and the systemic level. Over the last decade, the liver peptide "hepcidin" has emerged as the body’s key irons store regulator. The long postulated "erythroid regulator of iron", however, remained elusive. Last year, evidence was provided, that a previously described myokine "myonectin" may also function as the long sought erythroid regulator of iron. Myonectin was therefore renamed "erythroferrone". This editorial provides a brief discussion on the two functions of erythroferrone and also briefly considers the emerging potential role of transferrin receptor 2 in erythropoiesis.