Impact of circulating tumor cells in colorectal cancer patients undergoing laparoscopic surgery

• 作者: Chun-Chi Lin Jung-Jyh Hung Shung-Haur Yang Wei-Shone Chen
• 来源期刊: 世界外科手术杂志
• 学科: 医学
• 关键词: LAPAROSCOPIC SURGERY CIRCULATING TUMOR cell PROGNOSIS COLORECTAL cancer
• 年，卷（期）: sjwksszz_2015,（1）
• 页码范围: 75-81
• 页数: 7页
• 分类号: R

摘要

Laparoscopic surgery has recently been widely used for various benign colorectal diseases as well as colorectal cancer.Although laparoscopic surgery has been shown to be with similar prognostic results for certain groups of colorectal cancer patients.The influence of laparoscopic procedures on the oncologist results,especially free tumor cell spreading is still a concern for some surgeons.Tumor cells found in the peripheral blood of patients with cancer are termed circulating tumor cells(CTCs).Presence of CTCs in the peripheral blood of patients with colorectal cancer has been reported to be associated with disease stage,poor prognosis,tumor progression,response to therapy,and drug resistance.Whether laparoscopic procedure enhances tumor spreading during operation remains unknown.Significantly less CTC detected during laparoscopic surgery than open surgery for colorectal cancer has been reported.In our previous experience,no significant elevation in CTC level was found in most patients during laparoscopic resection of colorectal cancer.We have shown that laparoscopic surgery had no significantly deleterious effect on CTCs in colorectal cancer patients.In this review,we aim at the impact of CTCs in patients with colorectal cancer undergoing laparoscopic surgery.The prognostic significance of CTCs in patients with colorectal cancer will also be addressed.