A Decision Support System Based on Multi-Agent Technology for Gene Expression Analysis

• 作者: Alfredo Weitzenfeld Ana Espinosa Ana Lilia Laureano-Cruces Christian Lemaitre Edna Márquez Jaime Berumen Jesús Savage Ron Leder
• 来源期刊: 智能科学国际期刊(英文)
• 学科: 医学
• 关键词: MULTI-AGENT Systems MACHINE LEARNING BIOINFORMATICS GENE EXPRESSION Analysis
• 年，卷（期）: 2015,（3）
• 页码范围: 158-172
• 页数: 15页
• 分类号: R73

摘要

The genetic microarrays give to researchers a huge amount of data of many diseases represented by intensities of gene expression. In genomic medicine gene expression analysis is guided to find strategies for prevention and treatment of diseases with high rate of mortality like the different cancers. So, genomic medicine requires the use of complex information technology. The purpose of our paper is to present a multi-agent system developed in order to improve gene expression analysis with the automation of tasks about identification of genes involved in a cancer, and classification of tumors according to molecular biology. Agents that integrate the system, carry out reading files of intensity data of genes from microarrays, pre-processing of this information, and with machine learning methods make groups of genes involved in the process of a disease as well as the classification of samples that could propose new subtypes of tumors difficult to identify based on their morphology. Our results we prove that the multi-agent system requires a minimal intervention of user, and the agents generate knowledge that reduce the time and complexity of the work of prevention and diagnosis, and thus allow a more effective treatment of tumors.