SGF29 and Sry pathway in hepatocarcinogenesis

• 作者: Fumio Tashiro Nobuya Kurabe Shigekazu Murakami
• 来源期刊: 世界生物化学杂志：英文版（电子版）
• 学科: 医学
• 关键词: C-MYC SPT3-TAF9-GCN5-acetyltransferase COMPLEX SGF29 SRY HEPATOCARCINOGENESIS
• 年，卷（期）: 2015,（3）
• 页码范围: 139-147
• 页数: 9页
• 分类号: R735.7

摘要

Deregulated c-Myc expression is a hallmark of many human cancers. We have recently identified a role of mammalian homolog of yeast SPT-ADA-GCN5-acetyltransferas(SAGA) complex component, SAGAassociated factor 29(SGF29), in regulating the c-Myc overexpression. Here, we discuss the molecular nature of SFG29 in SPT3-TAF9-GCN5-acetyltransferase complex, a counterpart of yeast SAGA complex, and the mechanism through which the elevated SGF29 expression contribute to oncogenic potential of c-Myc in hepatocellularcarcinoma(HCC). We propose that the upstream regulation of SGF29 elicited by sexdetermining region Y(Sry) is also augmented in HCC. We hypothesize that c-Myc elevation driven by the deregulated Sry and SGF29 pathway is implicated in the male specific acquisition of human HCCs.