Modifications of L-Glutamine and L-Leucine Transport in Proliferating Lymphocytes

• 作者: Francisco Sanchez Jose Luis Gil Macarena Perán
• 来源期刊: 生物科学与医学(英文)
• 学科: 医学
• 关键词: Cell Membrane TRANSPORT LYMPHOCYTES L-GLUTAMINE L-LEUCINE MALIGNANCY Biomarkers
• 年，卷（期）: 2015,（3）
• 页码范围: 104-109
• 页数: 6页
• 分类号: R73

摘要

Lymphocytes respond to mitogens that stimulate proliferation by increasing theirs metabolic activity. In this study we investigate L-Glutamine and L-Leucine uptake as markers of cell response to Concavalina A (ConcaA) stimulation, using a high-resolution flow technique. We found that lymphocytes induced to blast transformation enhanced rate and efficiency of amino acid uptake during cell proliferation. Considering that increases in transport is the first quantifiable response of cells during malignant transformation, amino acid uptake could also be useful as an early marker of malignancy.