From nerve to blood vessel: a new role of Olfm2 in smooth muscle differentiation from human embryonic stem cell-derived mesenchymal cells

• 来源期刊: 生物医学研究杂志（英文版）
• 学科: 医学
• 年，卷（期）: 2015,（4）
• 页码范围: 261-263
• 页数: 3页
• 分类号: R394.1
• 语种: 中文
• DOI: 10.7555/JBR.29.20150027

摘要

Vascular smooth muscle cell (SMC) differentiation is an important process in vasculogenesis and angiogenesis during embryonic development.The alterations in the differentiated state in SMCs contribute to a variety of major cardiovascular diseases such as atherosclerosis,hypertension,restenosis and vascular aneurysm[1-2].A better understanding of the cellular and molecular mechanisms that control SMC differentiation is essential to help develop new approaches to both prevent and treat these diseases.Therefore,development of reliable and reproducible in vitro cellular models in order to study the differentiation mechanisms is important although it has been challenging because of intrinsic peculiarities of SMC.