Selective role of autophagy in neuronal function and neurodegenerative diseases

• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2015,（4）
• 页码范围: 379-381
• 页数: 3页
• 语种: 中文
• DOI: 10.1007/s12264-015-1551-7

摘要

Proteostasis is critical for neuronal maintenance and survival,and its imbalance leads to neurodegeneration with the hallmark of protein misfolding and aggregation[1].Macroautophagy becomes a major route for the clearance of protein aggregates that are normally poor substrates for the proteasome,the other protein quality-control machinery[2].As a flux process,macroautophagy (hereafter referred to as autophagy) involves the formation of the autophagosome,a double-membrane vesicle for engulfing unwanted cellular components such as protein aggregates,and the fusion of autophagosomes with lysosomes that contain many potent proteases for final degradation[3].