Possibilities of Experimental Modulation of Senescence by Stimulation of Antiradical Defense

• 作者: Codruta Badescu Madalina Mocanu Magda Badescu Manuela Ciocoiu Oana Badulescu
• 来源期刊: 生物医学工程(英文)
• 学科: 医学
• 关键词: SENESCENCE Zinc ASPARTATE Aronia melanocarpa OXIDATIVE Stress
• 年，卷（期）: swyxgcyw_2015,（4）
• 页码范围: 237-245
• 页数: 9页
• 分类号: R73

摘要

Various epidemiological studies have shown an inverse association between the consumption of polyphenols or polyphenol-rich foods and the risk of neurodegenerative, hepatic diseases. The research aimed to fight oxidative stress and lipid metabolism changes in the context of?administration?of antioxidants, such as polyphenolic extract of Aronia melanocarpa and zinc aspartate, known for its neurotrophic effects in intrinsic aging processes. Zinc aspartate and poly-phenolic extract from Aronia melanocarpa reduce oxidative stress values both in serum, liver homogenate, and in brain homogenate. Oxidative stress assessed by malondialdehyde (MDA), glutathione peroxidase (GPx) and total antioxidant capacity (TAC) markers was reduced in animals receiving additional zinc salts and polyphenolic extract of Aronia melanocarpa, which underlines their role in antioxidant defense. This combination produces more superior hypolipidemic and antioxidant effects than in the case of separate administration within experimental senescence induced in the murine model. Further studies will investigate the effect of different dose combinations of zinc aspartate and polyphenolic extract of Aronia melanocarpa at different periods of treatments on age-associated liver/cerebral dysfunction.