Structural insights into Rhino-mediated germline piRNA cluster formation

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2015,（4）
• 页码范围: 525-528
• 页数: 4页
• 语种: 中文
• DOI: 10.1038/cr.2015.10

摘要

Dear Editor, The piRNA pathway silences transposons in animal gonads.Animals lacking piRNA pathway components often show transposon activation in the germline and compromised fertility [1].In Drosophila germ cells,piRNA precursors are transcribed from heterochromatic piRNA cluster regions,and then transported into nuage/mitochondria to be processed into mature piRNAs that are loaded into PIWI clade Argonautes [1].Guided by piRNAs,PIWI proteins silence transposons at either transcriptional or post-transcriptional level [2].