Systemic Sarcoidosis Revealed by a Nasal Lesion: A Case Report

• 作者: Khaled Khammassi Madiha Mahfoudhi Mamia Ben Salah Sami Turki
• 来源期刊: 临床医学国际期刊(英文)
• 学科: 医学
• 关键词: SARCOIDOSIS NOSE GRANULOMA CORTICOSTEROIDS
• 年，卷（期）: 2015,（4）
• 页码范围: 257-261
• 页数: 5页
• 分类号: R5

摘要

A 62-year-old man presented with bilateral nasal obstruction and recurrent epistaxis episodes. Physical examination revealed normal body temperature and free cervical lymph nodes areas. Nasal endoscopy found a congestive nasal mucosa associated to bilateral inferior turbinate hypertrophy with a granular aspect of the right inferior turbinate. The biological examination showed lymphopenia, inflammatory syndrome, high serum level of angiotensin-converting enzyme and β2 microglobulin. Tuberculin skin test and Quantiferon gold were negative. The nasal and accessory salivary gland biopsies revealed granulomatous giant cell lesions non-caseating evoking systemic sarcoidosis. Ziehl-Neelsen staining and Lowenstein culture were negative. The diagnosis was systemic sarcoidosis revealed by nasal localization. The systemic extension research was negative. The treatment was based on corticosteroids (1 mg/kg/day) and gradual degression doses associated to a local nasal corticosteroid. The outcome was favorable with improvement of nasal obstruction and disappearance of initial lesions. The follow-up was 2 years.