Heart Histopathology and Oxidative Features in Diabetic Rats and Protective Effects of Oleuropein

• 作者: Hedya Jemai Sami Sayadi
• 来源期刊: 生命科学与技术进展(英文)
• 学科: 医学
• 关键词: ANTIOXIDANTS Diabetes HEART HEART HISTOLOGY OLEUROPEIN
• 年，卷（期）: 2015,（6）
• 页码范围: 383-389
• 页数: 7页
• 分类号: R5

摘要

Diabetes induced cardiac dysfunction and lesions are nowadays confirmed. In fact, Diabetes is a chronic metabolic disease, which is associated with oxidative stress and hyperglycaemia which have direct toxic effects on cardio-myocytes. Olive leaves extract compounds, such as Oleuropein, have been used in many therapeutic and preventive cases. The present study is designed to evaluate the effect of Oleuropein as antioxidant on the heart histological and oxidative features in diabetic rats. Diabetes was induced by alloxan at 180 mg/kg b.w by intra-peritoneal method once. Four weeks Oleuropein rich olive leaves administration restore significantly the heart histological alteration established by diabetes and enhanced the cardiac antioxidant potential.