A novel upconversion nanotheranostic agent for multi-modality imaging-guided chemotherapy with on-demand drug release

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2015,（6）
• 页码范围: 970
• 页数: 1页
• 语种: 中文
• DOI: 10.1007/s11426-015-5428-4

摘要

Lanthanide-doped upconverting nanoparticles (UCNPs) are a unique type of phosphor,which could convert two or more low-energy near-infrared (NIR) photons into a high-energy photon.This unique feature endows UCNPs with great potentials in a variety of applications,including solid-state lasers,three-dimensional flat panel displays,and especially bio-imaging.Most importantly,with proper surface modification and functionalization,UCNPs have been employed as anticancer drug nanocarriers in malignant tumor treatment.However,anticancer drugs usually release before they reach the target cancer cells,resulting in significant side effects and limited treatment efficiency.To tackle this issue,it is highly desirable to develop stimuli-responsive drug-delivery system based on UCNPs which could serve as contract agents for bio-imaging and on-demand drug release,but it remains a great challenge.