Resolving sorting mechanisms into exosomes

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2015,（5）
• 页码范围: 531-532
• 页数: 2页
• 语种: 中文
• DOI: 10.1038/cr.2015.39

摘要

The complexity of mechanisms driving protein sorting into exosomes is only beginning to emerge.In a paper recently published in Cell Research,Roucourt et al.report that trimming of heparan sulfate side chains of syndecans by endosomal heparanase facilitates sorting into exosomes by the formation of tight syndecan clusters that are recruited by the multivalent adaptor syntenin to the ALIX-ESCRT sorting machinery at endosomes.