HLA antigens and anti-sperm antibody production in Iranian vasectomized men

• 来源期刊: 生物医学研究杂志（英文版）
• 年，卷（期）: 2015,（1）
• 页码范围: 87-90
• 页数: 4页
• 语种: 中文
• DOI: 10.7555/JBR.29.20140113

摘要

Dear Editor: Anti-sperm antibodies (ASAs) are composed of numerous antibodies interacting with multiple sperm antigens that play a role in fertility.In males,ASAs cause ‘immune infertility’ by decreasing sperm counts and normal forms,as well as reducing sperm motility and viability,markedly reducing the likelihood of natural conception[1].The development of ASA in the male depends on the release of sequestered antigens on germ cells following the disruption of the blood-testis barrier.A surgical operation such as a vasectomy could also lead to immunogenic sperm antigens being exposed to the immune system,thus initiating an immune response to produce ASAs[2].