Co-participation of paternal and maternal genomes before the blastocyst stage is not required for full-term development of mouse embryos

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2015,（5）
• 页码范围: 486-488
• 页数: 3页
• 语种: 中文
• DOI: 10.1093/jmcb/mjv055

摘要

Dear Editor, The development of all the mammalian species begins from fertilization of a sperm and an egg into a diploid state.The maternal and paternal genomes are not functionally equivalent in term of their differential contributions to the imprinting gene expressions, and they are complementary and both essential for embryonic and postnatal development (McGrath and Solter, 1984;Surani et al., 1986).It is well known that the nucleus of blastomeres adopt a ‘Rabl configuration’ by which the paternal and maternal genomes separate spatially within the same nucleus until the 8-cell stage (Mayer et al., 2000;Santenardet al., 2010).