Repressors of reprogramming

• 作者: Melissa Popowski Haley Tucker
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: REPROGRAMMING INDUCED PLURIPOTENCY STEM CELLS
• 年，卷（期）: 2015,（3）
• 页码范围: 541-546
• 页数: 6页
• 分类号: R

摘要

Induced pluripotent stem cells （iPSCs） have been thefocal point of ever increasing interest and scrutiny asthey hold the promise of personalized regenerativemedicine. However, creation of iPSCs is an inefficientprocess that requires forced expression of potentiallyoncogenic proteins. In order to unlock the full potentialof iPSCs, both for basic and clinical research, we mustbroaden our search for more reliable ways of inducingpluripotency in somatic cells. This review surveysan area of reprogramming that does not receive asmuch focus, barriers to reprogramming, in the hopeof stimulating new ideas and approaches towardsdeveloping safer and more efficient methods ofreprogramming. Better methods of iPSC creation willallow for more reliable disease modeling, better basicresearch into the pluripotent state and safer iPSCs thatcan be used in a clinical setting.