The Effects of Antiretroviral Drugs on the Absorbance Characteristics of HIV-Infected Blood

• 作者: Chinonso Achebe Okwuchukwu Ani Sam Omenyi
• 来源期刊: 生物医学工程(英文)
• 学科: 医学
• 关键词: ABSORBANCE TRANSMITTANCE Dielectric Constant Human IMMUNODEFICIENCY Virus ANTIRETROVIRAL Drug Coating Effectiveness LYMPHOCYTE Wavelength
• 年，卷（期）: 2015,（9）
• 页码范围: 571-581
• 页数: 11页
• 分类号: R73

摘要

In the twenty first century research works, there may be a need to achieve a more reliable research result through a synergy between engineers and biological researchers. The peak absorbance data for various interacting systems were measured. These were used to show that the antiretroviral drug has the effect of increasing the peak absorbance values of both the uninfected and infected blood components, i.e., the drugs are made able to increase the light absorption capacity of the blood cells. For drug 2 that contains three components including Efavirenz, the drug effect on lymphocytes was increased by about 38% for patients that had been on antiretroviral drug treatment. Mathematical models were proposed and used in determining the coating effectiveness of antiretroviral drugs in the presence and absence of HIV. The use of the findings of this work by pharmaceutical industries may help in the search for more effective antiretroviral drugs for the treatment of HIV patients.