Optimal management of prostate cancer with lethal biology-state-of-the-art local therapy

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2015,（6）
• 页码范围: 888-891
• 页数: 4页
• 语种: 中文
• DOI: 10.4103/1008-682X.156855

摘要

Defining prostate cancer with lethal biology based upon clinical criteria ischallenging.Locally advanced/High-Grade prostate cancer can be downstaged or even downgraded with cure in up to 60％ of patients with primary therapy.1-5 However, what is known is that high-grade prostate cancers have a greater potential for recurrence and progression to metastatic disease, which can ultimately result in a patient's death.Patients with clinical features of "high-risk" prostate cancer (cT2c, PSA ＞20, ≥ Gl 8 on biopsy) are more likely to harbor more aggressive pathologicfindings.