Dominant-negative inhibition of glucose-dependent insulinotropic polypeptide impairs function of β cells in transgenic pigs

• 来源期刊: 生物医学研究杂志（英文版）
• 学科: 医学
• 年，卷（期）: 2015,（6）
• 页码范围: 512-514
• 页数: 3页
• 分类号: R714.256
• 语种: 中文
• DOI: 10.7555/JBR.29.20150046

摘要

Dear Editor: Glucose-dependent insulinotropic polypeptide (GIP) and proglucagon product glucagon-like peptide-1 (GLP-1) and their corresponding receptors promote secretion of glucose-dependent insulin[1] and may be responsible for up to 70％ of postprandial insulin secretions[2].A diminished incretin effect is typical for type 2 diabetes mellitus (T2DM) patients and their normoglycemic first-degree relatives due to reduced insulinotropic action of GIP[3].Desensitization of the GIP/GIPR axis[4],down-regulation of GIP receptor (GIPR) on β cells[5],and variation in the GIPR gene[6] all contribute to reduced insulinotropic activity of GIP.