The Level of Soluble FMS-Like Tyrosinkinase-1, Placental Growth Factor and Vitamin E in Pre-Eclampsia and Normotensive Pregnancy

• 作者: Janno Bernadus John Wantania Meilany Durry
• 来源期刊: 临床医学国际期刊(英文)
• 学科: 医学
• 关键词: SFLT-1 PLGF Vitamin E PRE-ECLAMPSIA NORMOTENSIVE PREGNANCIES
• 年，卷（期）: 2015,（7）
• 页码范围: 475-481
• 页数: 7页
• 分类号: R5

摘要

Background: This study aims to determine the differences of angiogenic markers sFlt-1 (soluble FMS-like tyrosine kinase-1), Placental Growth Factor (PlGF) and antioxidant (vitamin E) levels in pre-eclampsia compared with normotensive pregnancies. Methods: In a cross-sectional study performed on 40 normotensive pregnancies and 40 pre-eclampsia women, serum levels of sFlt-1, PlGF and vitamin E were measured with ELISA methods. Statistical analysis used Mann Whitney. Results: The serum levels from the group of normotensive pregnancy and pre-eclampsia women consecutively are as follows: sFlt-1 2251.32 ± 416.17 pg/mL and 2950.78 ± 221.34 pg/mL, having a very significant difference (p = 0.00);PlGF 391.67 ± 293.92 pg/mL and 150.15 ± 105.34 pg/mL, having a very significant difference;vitamin E 8537.21 ± 6299.74 unit and 700.61 ± 233.70 unit, having a very significant difference. Conclusion: There is a very significant difference between an-giogenic markers and antioxidant levels in pre-eclampsia and normotensive pregnancies.