Bio-cluster nano-bomb for cancer drug delivery: efficacious fire at the target

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2015,（3）
• 页码范围: 403-404
• 页数: 2页
• 语种: 中文
• DOI: 10.1007/s11434-014-0719-2

摘要

Along with molecular targeted drugs and antibody-drug conjugates (ADC),cancer nanomedicine has now been considered as one of the troika for advanced cancer treatment by delivering anticancer drugs to the tumor site with reduced side effects and enhanced therapeutic efficacy [1].As researchers learn more about cancer drug delivery process and tumor microenvironment [2],it is now recognized that nanomedicine must go through a CAPIR cascade of five steps,i.e.,long circulation in the blood,high accumulation in the tumor through the leaky tumor-feeding vasculature,deep penetration into the tumor tissue,tumor cell internalization,and finally intracellular drug release.<英作者单位一>Department of Biomedical Engineering,University of Minnesota,Minneapolis,MN 55455,USA