Dose-dependent regulation of oligodendrocyte specification by β-catenin signaling

• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2015,（2）
• 页码范围: 271-273
• 页数: 3页
• 语种: 中文
• DOI: 10.1007/s12264-014-1513-5

摘要

Dear Editor, Although various components of the Wnt/β-catenin pathway have been investigated,there are conflicting reports on the roles of Wnt/β-catenin signaling in oligodendrogenesis and differentiation.For instance,the/△Exon3 mutation of β-catenin[1-4],which stabilizes β-catenin by deletion of the phosphorylation site for the destruction complex,significantly inhibits the differentiation of oligodendrocytes,but knockout of β-catenin also delays it[4].In addition,overexpression of dominant-negative (dn) forms of Tcf/Lef increases the number of oligodendrocyte progenitors (OLPs)[3,5],and knockout of Tcf7I2 (also known as Tcf4)impairs myelin formation[3,6].In contrast,another study showed that overexpression of dnTcf7I2 decreases the number of OLPs[7].