Base-resolution maps of 5-formylcytosine and 5-carboxylcytosine reveal genome-wide DNA demethylation dynamics

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2015,（3）
• 页码范围: 386-389
• 页数: 4页
• 语种: 中文
• DOI: 10.1038/cr.2015.5

摘要

Dear Editor, The TET family of dioxygenases can oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC),5-formylcytosine (5fC),and 5-carboxylcytosine (5caC)in mammalian genomic DNA via a stepwise manner [1-5].5fC and 5caC are selectively recognized and excised by mammalian thymine DNA glycosylase (TDG),and restored to normal cytosine through base excision repair [3,6-9].Once converted to 5fC and 5caC,the modified cytosine base is presumably committed to demethylation through the TDG-dependent pathway or other potential mechanisms.Thus 5fC and 5caC specifically mark active demethylation in the mammalian genome.