Regulation of sperm capacitation and the acrosome reaction by PIP2 and actin modulation

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2015,（4）
• 页码范围: 597-600
• 页数: 4页
• 语种: 中文
• DOI: 10.4103/1008-682X.154305

摘要

Actin polymerization and development of hyperactivated (HA) motility are two processes that take place during sperm capacitation.Actin polymerization occurs during capacitation and prior to the acrosome reaction,fast F-actin breakdown takes place.The increase in F-actin during capacitation depends upon inactivation of the actin severing protein,gelsolin,by its binding to phosphatydilinositol-4,5-bisphosphate (PIP2) and its phosphorylation on tyrosine-438 by Src.