Multipotent pancreas progenitors： Inconclusive but pivotaltopic

• 作者: Fang-Xu Jiang and Grant Morahan
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: MULTIPOTENT PANCREAS progenitors REGENERATION SELF-RENEWAL Clonogenesis DIFFERENTIATION
• 年，卷（期）: 2015,（11）
• 页码范围: 1251-1261
• 页数: 11页
• 分类号: R

摘要

The establishment of multipotent pancreas progenitors（MPP） should have a significant impact not only on theontology of the pancreas, but also for the translationalresearch of glucose-responding endocrine b-cells.Deficiency of the latter may lead to the pandemic type1 or type 2 diabetes mellitus, a metabolic disorder.An ideal treatment of which would potentially be thereplacement of destroyed or failed b-cells, by restoringfunction of endogenous pancreatic endocrine cells orby transplantation of donor islets or in vitro generatedinsulin-secreting cells. Thus, considerable research effortshave been devoted to identify MPP candidates in the preandpost-natal pancreas for the endogenous neogenesisor regeneration of endocrine insulin-secreting cells. Inorder to advance this inconclusive but critical field, wehere review the emerging concepts, recent literatureand newest developments of potential MPP and proposemeasures that would assist its forward progression.