Direct C-H functionalization has become one of the most important and emerging topics in organic synthesis.In this regard,Chinese chemists have made significant contributions for promoting the study of such chemistry from different aspects.Encouraged by the considerable progress made in this field by Chinese organic chemists,particularly the young generation of organic chemists in mainland China,it only seems apt to organize a special issue on the recent advances in C-H functionalization with the aim of stimulating in-depth research on the future development of,and potential applications for,this important evolving field.By focusing on the dynamic aspects of C-H activation,18 papers have been included in this special issue,including two perspectives,two reviews,one feature article,and thirteen research articles.