Is PAWP the "real" sperm factor?

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2015,（3）
• 页码范围: 444-446
• 页数: 3页
• 语种: 中文
• DOI: 10.4103/1008-682X.142145

摘要

Mammalian embryo development is initiated by intracellular Ca2+ oscillations that result in oocyte activation following gamete membrane fusion.It is widely believed that oocyte Ca2+ oscillations are triggered by a sperm-specific protein,phospholipase C-zeta (PLCζ) that activates InsP3 production leading to repetitive Ca2+ release from intracellular stores.However,a recent report in the FASEB Journal by Aarabi et al.challenges this view by proposing postacrosomal WW domain-binding protein (PAWP) as another sperm-derived protein that can also initiate Ca2+ oscillations and zygotic development at fertilization.Here we discuss these new findings and examine the evidence suggesting PAWP as the "real" sperm factor.