Comment on reversal of hypogonadotropic hypogonadism in a Chinese cohort
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摘要:
The reversal of congenital hypogonadotropic hypogonadism (CHH) is a relatively recent phenomenon that has gained increasing attention over the past 10 years.Yet to date,only one prospective study has been conducted estimating that 10% (95% confidence interval [CI]:2%-18%) of cases undergo reversal,1 Other retrospective studies have reported rates in the range of 5%-8%2,3 and a recent study showed 44/308 (14%,95% CI:11%-19%) CHH patients underwent reversal,4 Moreover,a time-to-event analysis in this large cohort revealed a lifetime reversal incidence of 22%.